Comparison of oral versus topical tranexamic acid for treatment of melasma

: Melasma is one of the most common causes hyperpigmentation and a prevalent cosmetic concern for patients. Tranexemic acid an effective mode treatment available in both oral topical forms. To evaluate compare therapeutic effectiveness tranexamic melasma. A total 84 patients who presented to dermatology OPD with melasma were divided into two groups, namely B. Group treated 250 mg twice daily, B 5% follow-up every 4 weeks until 3 months. Among patient statistically significant difference mean percentage reduction MASI score from baseline was observed at 12 (61.31±9.48 vs 52.64±8.03 topical) p<0.05. Systemic side effects like abdominal pain, nausea, oligomenorrhea tranexemic acid, while erythema, skin irritation, xerosis treatment. Oral gave more promising result when compared acid. Despite having GI disturbances it had compliance could be approach